Ultrasonic Drug Extraction And Pharmaceutical Purification Process

Ultrasonic Drug Extraction And Pharmaceutical Purification Process
 
 
Description: 
 
Ultrasonic drug extraction and pharmaceutical purification process is a technology that utilizes the mechanical vibration and cavitation effect of ultrasound to enhance the efficiency of drug extraction. Crush the selected medicinal herbs to an appropriate particle size to increase surface area and improve extraction efficiency; Select appropriate solvents based on their medicinal properties, such as water, alcohols, ethyl acetate, etc; Mix the crushed medicinal herbs with a solvent and place them in an ultrasonic extraction device. Set the appropriate ultrasonic frequency (usually 20-40 kHz) and processing time (usually 30 minutes to several hours); The cavitation effect generated by ultrasound allows solvents to penetrate into the interior of medicinal herbs, promoting the release of active ingredients, and then performing extraction; After extraction, the solid residue is removed by filtration to obtain the extraction solution. The extraction solution is then concentrated using a rotary evaporator or other concentration equipment to increase the concentration of active ingredients; Finally, the extract was purified using methods such as column chromatography and crystallization.
 
 
Parameters:
 

 
 
Parameters Influence :
 

1. Properties of medicinal herbs Hardness and fibrosis: Hard medicinal herbs (such as rhizomes) usually require longer extraction time and higher ultrasonic power, while soft herbs (such as flower petals) are relatively easy to extract. Solubility of active ingredients: The solubility of active ingredients in different solvents varies among different medicinal herbs, which can affect the selection of solvents and extraction efficiency.

2. Ultrasonic frequency Low frequency (20-30 kHz): suitable for hard medicinal materials, can produce stronger cavitation effect. High frequency (30-40 kHz): Suitable for delicate medicinal herbs, it can reduce damage to the herbs.

3. Ultrasonic power Power setting: Excessive power may result in excessive heat and damage to certain thermosensitive components; If the power is too low, the extraction efficiency may be insufficient. It is generally recommended to adjust between 100-500 W.

4. Extraction time Short term (within 30 minutes): suitable for rapid extraction, mainly used for thermosensitive components. Long term (more than 1 hour): Suitable for medicinal herbs that require sufficient release of active ingredients, usually used for root and stem medicinal herbs.

5. Temperature control Room temperature extraction: suitable for thermosensitive components to prevent degradation. Heating extraction: For some active ingredients, increasing the temperature appropriately (such as 60 ° C) can accelerate the extraction process, but attention should be paid to controlling the temperature to avoid loss.

6. Solvent selection Polar solvents, such as water and ethanol, are suitable for extracting polar components. 
 
 
Examples: 
 

1. Ginseng: Usually water or ethanol is used, with an ultrasonic power of 200-300 W and an extraction time of 1 hour.

2. Huanglian: Use water or alcohol, with a power of 100-200 W and an extraction time of about 30 minutes.

3. Goji berries: commonly extracted with water, with a power of 200 W and a time of 30 minutes.
 
 
Ultrasonic Drug Extraction And Pharmaceutical Purification Process